gut.bmj3d
The national colonoscopy audit: a nationwide assessment of the quality and safety of colonoscopy in the UK
2 Department of Gastroenterology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham General Hospital, Cheltenham, UK 3 Department of Gastroenterology, Gloucestershire Hospitals NHS Foundation ...
gut.bmj5d
Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction
Objective An international meeting was organised to develop consensus on (1) the landmarks to define the gastro-oesophageal junction (GOJ), (2) the occurrence and pathophysiological significance of ...
gut.bmj7d
UK guidelines for management of acute pancreatitis: is it time to change?
Department of General Surgery, Buckinghamshire Hospitals NHS Trust, Aylesbury, UK Correspondence to: MrK Gurusamy Department of General Surgery, Buckinghamshire Hospitals NHS Trust, 5 North Drive, ...
gut.bmj7d
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing
Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...
gut.bmj7d
Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer
Correspondence to Professor Xian-Jun Yu, Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; yuxianjun88{at}hotmail.com Design We combined molecular ...
gut.bmj8d
PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma
Objective Patients with increased PD-L1 + host cells in tumours are more potent to benefit from antiprogrammed death-1/programmed death ligand-1 (PD-L1) treatment, but the underlying mechanism is ...
gut.bmj10d
PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis
1 Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, USA 2 Division of Biostatistics, Mayo Clinic and Foundation, Rochester, MN, USA Correspondence to: Dr E V ...
gut.bmj16d
p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett’s oesophagus
Background While p53 mutations occur early in Barrett’s oesophagus (BE) progression to oesophageal adenocarcinoma (EAC), their role in gastric cardia stem cells remains unclear. Objective This study ...
gut.bmj18d
Challenge of treatment de-escalation in inflammatory bowel diseases
Inflammatory bowel diseases (IBDs) encompass chronic conditions predominantly affecting young individuals and necessitate long-term, advanced treatments to manage disease burden and mitigate ...
gut.bmj25d
Induction of macrophage efferocytosis in pancreatic cancer via PI3Kγ inhibition and radiotherapy promotes tumour control
Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways ...
gut.bmj28d
Unsolved mysteries of intestinal M cells
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